Posted on Sep 25, 2023

Advancements in Alzheimer's Research

Advancements in Alzheimer's Research: Prevention and Treatment

While ongoing research continuously uncovers potential treatments for Alzheimer's disease, the latest studies are also placing a strong emphasis on preventing the disease and mitigating its symptoms.

Understanding Alzheimer's Disease

Alzheimer’s disease, a form of dementia, predominantly affects Americans aged 65 and older, leading to cognitive decline and premature death. This disease disrupts the brain's ability to transmit information through neurons, resulting in cognitive impairment and memory loss.

Exploring Alzheimer's Causes

Alzheimer's risk tends to increase with age, making it a more significant concern for older individuals, particularly those with specific genetic factors. While a family history of Alzheimer's doesn't guarantee you'll develop it, understanding your family's medical background can help assess your risk. Early-onset Alzheimer’s,, affecting around 1% of all patients, appears to have a stronger genetic component.

Researchers believe various factors, from lifestyle choices to environmental influences, can either raise or lower the risk of developing dementia. Although there isn't a foolproof method to prevent Alzheimer's, researchers are optimistic about potential preventive measures, as discussed below.

Recognizing Early Signs of Alzheimer's Disease

Identifying early signs of Alzheimer's is crucial for prevention. These signs may include:

  • Significant memory loss that disrupts a person’s daily life
  • Trouble keeping track of money, bills, and other financial responsibilities
  • Mood swings and personality changes
  • Difficulty maintaining personal hygiene
  • Losing track of time

Risk Factors and Ongoing Research

While there's no definitive Alzheimer's prevention strategy currently, promising research is shedding light on the disease and potential avenues to reduce the risk or slow its progression.

A4 Trial Study

A study known as the A4 trial investigated the use of antibodies to decrease Alzheimer's risk in individuals over 65. The study aimed to assess whether reducing amyloid protein levels in the body with effective antibodies could slow down memory loss linked to amyloid protein buildup. Unfortunately, the trial did not yield the anticipated results, but it did confirm that elevated amyloid protein levels contribute to memory loss.

Studies on Genetic Mutations

The Dominantly Inherited Alzheimer Network is currently researching known genetic mutations  that almost guarantee the development of Alzheimer's in carriers as they age. These mutations are associated with early-onset Alzheimer's, affecting around 1 percent of all Alzheimer’s patients

Beta-amyloid plaque is located inside the brain and is suspected by researchers to cause cell and tissue death leading to Alzheimer’s disease. Clinical trials led by these researchers are looking at drugs that may reduce the progression of beta-amyloid plaque buildup. 

Cautions About Benzodiazepines

Individuals at risk of Alzheimer's, particularly those over 65, should consult their healthcare providers if prescribed benzodiazepines for anxiety or depression. Alzheimer's disrupts neurotransmitter communication in the brain, while benzodiazepines are depressant drugs that slow down brain activity. According to some research, long-term use of these drugs, especially in older adults, poses potential risks. Although other studies on whether they directly cause dementia is inconclusive.

Potential Links to Heartburn Medication

According to a recent study, long-term use of specific over-the-counter heartburn medications, like Prilosec, Nexium, and Prevacid, has been tentatively linked to a 33% increase in dementia risk among older adults, according to recent research. However, further investigation is required to establish a definitive connection.

Blood Pressure Medications as a Potential Benefit

Conversely, some analyses suggest that patients controlling high blood pressure with prescription drugs may have a lower risk of developing dementia than those leaving hypertension untreated.

Air Pollution and Alzheimer's

Exposure to poor air quality over time, including smoke from wildfires, traffic exhaust, and agricultural emissions, might be associated with dementia development, as suggested by researchers.

Technological Advancements in Alzheimer’s Diagnosis 

Technological advancements in diagnosis may help researchers to understand more of the signs of dementia and Alzheimer’s. 

One of the earliest signs of Alzheimer’s is struggling with speech, whether it is struggling to find the words during a conversation or keeping up a conversation with someone. Speech patterns help doctors understand a patient’s level of cognitive impairment. Artificial intelligence could aid medical professionals in analyzing speech and language patterns that may help catch the early signs of dementia and Alzheimer’s. 

Other studies are exploring the effectiveness of diagnosing Alzheimer’s early with a headband device that monitor’s a person’s brain activity. Individuals may even seek out a simple blood test that is newly available for predicting risk of the disease

Reducing Risk Through Lifestyle Changes

Although there's no guaranteed Alzheimer's prevention method, adopting a healthy lifestyle may help reduce the risk. This includes maintaining a nutrient-rich diet, regular exercise, mental stimulation through puzzles and activities, and engagement in social interactions. An active social life, especially as you age, can help preserve cognitive function, prevent memory loss, enhance communication skills, and promote overall well-being.

Read the full news article by Elder Law Answers here.